Well quite a bit could be said on this topic, but suffice it to say, there are a lot of winning approaches. One thing I can tell you, is that if you choose all the #1 & #2 seeds, you will not win! The idea is to pick teams that outperform the expectation of their seeds.
I'll share a FACT. Almost every year, there are one or two very high scoring teams (i.e. high seeds that make Final 8 or better), and if you don't have these teams in your 8 picks you will not win. For example, in 2022 UNC made the Championship game as an #8 seed. They were worth 120 points in the Pick8. 48 of the top 49 places in the Pick8 in 2022 had selected UNC. The Tarheels were effectively table stakes. If you didn't have them, you did not have a chance! In 2023, it was NC State as an 11 seed. The Wolfpack made the Final 4 for 110 points, and 73 of the top 74 entries in the Pick8 selected NC State.
Check out the History tab for some winning ideas, or talk to a friend for advice, or look below for some hot tips!.